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Oncolytic viruses

Our research is focused on the use of oncolytic viruses as treatment option for patients with untreatable solid tumors. Oncolytic viruses (OVs) are viruses that selectively infect and damage malignant tumors without damaging normal tissues, and are employed in what is called oncolytic virotherapy.

OV therapy results in direct tumor killing and local inflammation which leads to activation of the adaptive immune system. OV induced therapeutic stimulation of the immune system could be enhanced by increasing the immune stimulation elicited in virus-infected cancer cells by incorporating immune stimulating genes into the virus and/or by combining virotherapy with immunotherapy. 

To rapidly develop and implement viro-immunotherapy as a treatment modality for cancer, we collaborate in the Dutch Oncolytic Viro-Immuno Therapy consortium (OVIT) in which the necessary expertise in virology, immunology, immunotherapy and the clinic is bundled. This consortium focuses on the use of on three OVs: Newcastle disease virus, reovirus and adenovirus for the treatment of patients with pancreatic-, prostate and brain cancer.

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Ongoing research projects

The Oncolytic viruses group of the Department of Virology of the Erasmus MC has two ongoing research projects:

  • The use of NDV as oncolytic virus for treatment of solid tumors
  • The use of Adenovirus and reovirus as oncolytic virus for treatment of solid tumors
      

Get to know these research projects and studies by scrolling down.
  

The use of NDV as oncolytic virus for treatment of solid tumors
  

Research team:

B.G. van den Hoogen, PhD
Prof. Ron Fouchier, PhD
Prof. Casper  van Eijck (Department of Surgery, Erasmus MC)
Stefan van Nieuwkoop, BSc  

Selections of publications:


The use of Adenovirus and reovirus as oncolytic virus for treatment of solid tumors
 

Research team:

Bernadette van den Hoogen, PhD
Prof. Ron Fouchier, PhD
Stefan van Nieuwkoop, BSc
Martine Lamfers, PhD (Department of Neurosurgery, Brain Tumor Center Erasmus MC)
Prof. Casper van Eijck (Department of Surgery, Erasmus MC

Selection of publications: