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Norovirus infections are a major cause of gastroenteritis in the general population worldwide. In healthy individuals norovirus infections are self-limiting, however in immunocompromised individuals infections are much more severe and can result in chronic disease.

There are more than 30 antigenically distinct norovirus genotypes, with highly variable prevalence in the community. In addition, noroviruses evolve over time and novel norovirus variants frequently (re-) emerge in the human population.  Our research focuses on the identification of viral traits and host factors that regulate infection as well as norovirus prevalence and evolution in humans and animals. This information will provide key insights necessary for the development of therapeutic and prevention strategies.