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Biology Image Guided Radiotherapy (BIGRT)

Development and pre-clinical validation of biology imaging techniques, Integration of biology imaging in RT planning and adaptive RT and Exploitation of biology imaging for optimizing multi-modality treatment strategies

Although modern radiotherapy is becoming ever more precise, it is based on discrimination of the target and the organs at risk using anatomical imaging only. In addition, current radiotherapy is based on the assumption that tumors and normal tissues are homogeneous, and so is their response to treatment homogeneous. Accumulating evidence shows that this homogeneity assumption is incorrect. The new research pillar on Biology Imaging Guided Radiotherapy (BIGRT), aims at exploiting biology imaging to capture the aberrant (molecular and physiological) characteristics of the tumor. BIGRT specifically aims at identifying regions in the tumor and normal tissue to enable to adapt the treatment accordingly. In this way, BIGRT aims at exploiting the features of advanced radiotherapy to tailor the dose delivery in the tumor and normal tissues to maximize treatment effectiveness and minimize or avoid treatment side effects.

Aims of BIGRT:
1. Development and pre-clinical validation of biology imaging techniques
2. Integration of biology imaging in RT planning and adaptive RT
3. Exploitation of biology imaging for optimizing multi-modality treatment strategies

BIGRT

Contact:
Maarten Paulides and Steven Petit