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Tissue engineering of Cartilage and Mucosa

1) Tissue engineering of Cartilage and Mucosa 


Damaged cartilaginous structures will not repair very well spontaneously. A lesion in cartilage will therefore in the long run lead to degeneration and deformation of the structure. In our research group various projects are being performed aiming at reparation of cartilage defects in future. This research line is a collaboration of the Dept Orthopaedics and Otorhinolaryngology.
The following research projects are involved:
" A novel approach to stimulate cartilage repair: targeting collagen turnover (funded by the Dutch Arthritis Association)
" Fine-tuning cartilage differentiation: controlled engineering of cartilage (funded by the Dutch Program for Tissue Engineering, STW)
" Tissue engineering endochondral ossification (funded by EU Marie Curie grant)

After excessive tumor resection surgery in Head and Neck Surgery, large mucosal defects often remain. These defects heal poorly, and lead to an increased risk of development of airway stenosis. This research is a collaboration of the Dept of Otorhinolaryngology and the Dept of Plastic and Reconstructive surgery, and involves cell- and tissue culture as well as animal experiments.

2) Airway injury
The Otorhinolaryngology Department in Erasmus Medical Center Sophia is a referral center for airway pathology in infants and children. Pathology includes stenosis after prolonged intubation, congenital disorders, infections, and tumours. Several smaller clinical studies concern difficult intubation, aspiration of foreign bodies, obstructive sleep apnoea in craniofacial malformation, and analysis of stridor sounds.
In a larger project we study the incidence and riskfactors of intubation injury in the neonatal and paediatric intensive care units. In this project we will focus on infectious and toxic influences, which may play a role in the development of laryngeal stenosis.

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