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GI Genetics

The GI genetics group focuses on the development of the gastrointestinal (GI) tract. The gastrointestinal (GI) tract is essential for transporting, absorbing, digesting, and excreting food and waste, but also for protecting the host from ingested pathogens, allergens, and toxins. It continuously is monitoring and responding to the state of the intestinal lumen. Our research has two main objectives. Which genetic factors determine the length of the GI tract, in particular the small intestine and the colon and secondly which genetic factors are important for the development of the enteric nervous system, a network of neurons and glial cells  located along the length of the GI tract and representing an important component of the autonomic nervous system.
To do so we focus on patients suffer from a congenital short bowel and on patients having Hirschsprung disease.


Congenital Short Bowel Syndrome