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Publications

Tsarouchas TM, Wehner D, Cavone L, Munir T, Keatinge M, Lambertus M, Underhill A, Barrett T, Kassapis E, Ogryzko N, Feng Y, van Ham TJ, Becker T, Becker CG.(2018)
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration. Nat Commun. 2018 Nov 7;9(1):4670. PubMed PMID: 30405119

Oosterhof N, Kuil LE, van der Linde HC, Burm SM, Berdowski W, van Ijcken WFJ, van Swieten JC, Hol EM, Verheijen MHG, van Ham TJ. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Rep. Jul 31;24(5):1203-1217.e6. PubMed PMID: 30067976. https://www.cell.com/cell-reports/pdfExtended/S2211-1247(18)31070-2

Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM. (2017) Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome Biol. Mar 8;18(1):48. PubMed PMID: 28274275

Nynke Oosterhof, Inge R. Holtman*, Laura E. Kuil*, Herma C. van der Linde, Erik W.G.M. Boddeke, Bart J.L. Eggen, Tjakko J. van Ham (in press) Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish, GLIA, DOI: 10.1002/glia.23083

Palchaudhuri R, Lambrecht MJ, Partlow KC, Botham RC, Van Ham TJ,  Putt KS, Nguyen LT, Kim S-H, Peterson RT, Fan TM, Hergenrother PJ (2015) A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed, Cell Reports, Dec 1;13(9):2027-36.

Jeroen Kuipers, Tjakko J. van Ham, Ruby D. Kalicharan, Anneke Veenstra-Algra, Klaas A. Sjollema, Freark Dijk, Ulrike Schnell$ and Ben N. G. Giepmans (2015) FLIPPER, a combinatorial probe for quantitative correlated live imaging and electron microscopy, Cell Tissue Res, Apr;360(1):61-70.

Nynke Oosterhof, Erik Boddeke, Tjakko van Ham, Immune cell dynamics in the brain: learning from the zebrafish, GLIA, May, 63 (5): 719-735 (cover image) 

Tjakko J van Ham*, Colleen A Brady, Ruby D. Kalicharan, Nynke Oosterhof, Jeroen Kuipers, Anneke Veenstra-Algra, Klaas A Sjollema, Randall T Peterson, Harm H Kampinga and Ben NG Giepmans (2014) Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation, Dis Model Mech, Jul;7(7):857-69.
Featured in special issue: zebrafish models for translational medicine & editorial: http://dmm.biologists.org/content/7/7/731.full
*Corresponding author

David Kokel, Timothy W Dunn, Misha B Ahrens, Ruediger Alshut, Chung Yan J Cheung, Louis Saint Amant, Giancarlo Bruni, Rita Mateus, Tjakko J van Ham, Tomoya Shiraki, Yoshitaka Fukada, Daisuke Kojima, Jing-Ruey J Yeh, Ralf Mikut, Johannes von Lintig, Florian Engert and Randall T. Peterson (2012), Identification of non-visual photomotor response cells in the vertebrate hindbrain, Journal of Neuroscience Feb 27;33(9):3834-43

Shan Jin, Kumar Sarkar, Yan Liu, David Kokel, Tjakko van Ham, Lee Roberts, Robert Gerszten, Calum MacRae, Randall Peterson (2012) An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. Journal of Biomolecular Screening, Jan;18(1):108-15

Tjakko J van Ham, David Kokel, Randall T Peterson (2012) Apoptotic cells are cleared by directional migration and elmo1-dependent macrophage engulfment. Current Biology, May 8;22(9):830-6.

Gabriele S Kaminski Schierle, Carlos W Bertoncini, Fiona TS Chan, Annemieke T van der Goot, Stefanie Schwedler, Jeremy Skepper, Simon Schlachter, Tjakko van Ham, Alessandro Esposito, Janet R Kumita, Ellen A A Nollen, Christopher M Dobson, Clemens F Kaminski (2011) A FRET sensor for non-invasive imaging of amyloid formation in vivo. Chemphyschem, Feb 25;12(3):673-80.

Tjakko J van Ham, James Mapes, David Kokel, Randall T Peterson (2010) Live imaging of apoptotic cells in zebrafish. FASEB J,Nov;24(11):4336-42

Tjakko J van Ham, Alessandro Esposito, Janet R Kumita, Shang-Te D Hsu, Gabriele S Kaminski Schierle, Clemens F Kaminski, Christopher M Dobson, Ellen A A Nollen, Carlos W Bertoncini (2010) Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation. J Mol Biol, Jan 22;395(3):627-42

Tjakko J van Ham, Mats A Holmberg, Annemieke T van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G Jerre van Veluw, Robert M W Hofstra, David C Rubinsztein, Ellen A A Nollen (2010) Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell, Aug 20;142(4):601-12

Tjakko J van Ham, Rainer Breitling, Morris A Swertz, Ellen AA Nollen (2009) Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Mol Med Nov;1(8-9):360-70.

Cintia Roodveldt, Carlos W Bertoncini, August Andersson, Annemieke T van der Goot, Shang-Te Hsu, Rafael Fernández-Montesinos, Jannie de Jong, Tjakko J van Ham, Ellen A Nollen, David Pozo, John Christodoulou, Christopher M Dobson (2009) Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO J, Dec 2;28(23):3758-70

Tjakko J van Ham, Karen L Thijssen, Rainer Breitling, Robert MW Hofstra, Ronald HA Plasterk, Ellen AA Nollen (2008) C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet, Mar 21;4(3):e1000027

Tjakko J van Ham and Ellen AA Nollen. (2011) Caenorhabditis elegans as a Model Organism for Dementia, Animals modles of dementia, Peter Paul De Deyn and Debby Van Dam (eds.), Animal Models of Dementia, Neuromethods, 2011, Volume 48, Part 4, 241-253