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Pim Pijnappel

W.W.M. Pim PijnappelAfbeelding
Associate Professor Molecular Stem Cell Biology

e-mail: w.pijnappel@erasmusmc.nl
tel: 010-7037864
fax 010-7044736

Shipping address

Dept Clinical Genetics , Erasmus MC
RM Ee0971
W.W.M. Pim Pijnappel, PhD
Wytemaweg 80
3015 CN Rotterdam
The Netherlands
Phone: +31-10-7037864

Pim Pijnappel obtained his MSc in Medical Biology at the Utrecht University (The Netherlands). In 1996, he obtained his PhD at the same university. He performed post-doctoral research at the EMBL (Heidelberg, Germany) and the Max Planck Institute (Dresden, Germany). In 2003, he became Head of the Netherlands Proteomics Biological Research Center at the UMC Utrecht. In 2012, he was appointed Head of Basal Research at the Center for Lysosomal and Metabolic Diseases at the Erasmus MC, Rotterdam.

Pim Pijnappel is interested in stem cells, gene expression and genome engineering. He pioneered identification of SET-domain protein complexes involved in epigenetic regulation of gene expression (Genes and Development, 2001). Using homologous recombination in E.coli (Red/ET recombination) he created versatile knock-in alleles in transgenic mice (Nature Biotechnology, 2003). His recent work identified the basal transcription factor TFIID as an important regulator of pluripotency in embryonic stem cells and during reprogramming to iPS cells (Nature, 2013). In 2012 he moved to the Erasmus MC to the Center for Lysosomal and Metabolic Diseases. Here he applies advances in stem cell biology and genetic engineering to disease modeling and the development of novel therapies for lysosomal storage disorders. His group works on skeletal muscle, cartilage, and the central nervous system in homeostasis and human disease including Pompe disease and Mucopolysaccharidoses (MPS).