... / ... / ... / Principal Investigators / Ingrid van de Laar, MD, PhD

Ingrid van de Laar, MD, PhD

Ingrid van de Laar, MD, PhD  Ingrid van de Laar
Clinical Geneticist

Department of Clinical Genetics
Erasmus MC
Faculty Building, Ee-2024
Wytemaweg 80

3015 CN Rotterdam 

The Netherlands  

Email: i.vandelaar@erasmusmc.nl
Tel: +31 (0) 10 7038445



In my work as a clinical geneticist I mainly see (parents or family members of) people with a hereditary heart condition, congenital abnormality and / or intellectual disability. The clinical genetics course is very dynamic and our genetic knowledge increases enormously rapidly. It fascinates me every day to correctly interpret the results of the (new) genetic tests and, at least as important, to communicate them clearly to the people and doctors involved. In addition, I find it very important to deal with the consequences of the genetic disorder for a person's well-being.


Work experience & training

I studied medicine at Utrecht University and then my training as a clinical geneticist at Erasmus MC. In 2012 I obtained my PhD at Erasmus MC, department of Clinical Genetics with research into the genetic causes of cardiovascular vascular abnormalities: 'Clinical and genetic studies in inherited cardiovascular malformations'. Since 2009 I have been working as a clinical geneticist at this department of Clinical Genetics, with a focus on cardiogenetics (aortic disorders, congenital heart defects, cardiomyopathies), general genetics and neurogenetics.


We do fundamental and translational research. Our basic aneurysm research is focused on discovering the causes of aneurysm formation and growth. An important part of this is finding the genes that are responsible for the development of an aortic aneurysm. In addition, we want to understand the function of an aneurysm gene, after which we can find out which processes in the tissue and in the cell the gene has an effect on. Determining this function takes place in cells by switching off a gene, and then studying the effect on the cell. Think for example of the growth or the shape of a cell. We can also make the gene product visible in the cell with a coloration, and follow it in the cell. We also use aneurysm tissue, in which we study the expression of genes. This gives us an idea of ​​the affected gene, and the processes that play a role in this. In our aneurysm model systems we look at aneurysm formation through molecular imaging and analysis. We then link these findings to (bio) markers that we discover through our gene expression experiments. Our ultimate goal is to develop intervention methods that focus on the specific processes that are affected within a family with aneurysms. In our translational aneurysm research, we examine, based on the processes we have discovered, what possibilities there are for early diagnosis and therapy. In both forms of research we work closely with the doctors in the clinic.


Cardio, Aortic Aneurysm, Aorta, Genetic Counseling, Genetic Epidemiology, Thoracic Aortic Aneurysm, Aortic Diseases, Human Molecular Genetics, Aneurysm, Clinical Genetics, Aortic, Aneurysm, Aorta


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