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Associates and Alumni

Foto Andre Hoogeveen

Andre Hoogeveen
In Fragile X syndrome a triplet repeat expansion in the 5’ UTR of the FMR1 gene usually coincides with hypermethylation and transcriptional silencing. We are interested in the epigenetic mechanism that results in the silencing of this gene. Further we study the function(s) of the FMR1 gene product (FMRP) and a family of fragile X related proteins (FXR1P and FXR2P).

The Myeloid Translocation Gene products (MTG8(ETO), MTGR1 and MTG16) are a family of transcriptional co-repressors. We are interested in the epigenetic regulation of these proteins and the role they play in leukaemia and breast cancer.

  100px x 133px_Ben Oostra

Ben Oostra
Emeritus Professor

  100px x 133px_Arnold Reuser

Arnold Reuser
Lysosomal storage diseases are caused by inherited genetic defects that impair essential functions of the human body and typically manifest as chronic, progressive, illnesses with -long term- fatal outcome. Our research activities are aimed to diagnose and understand the clinical presentations of these diseases starting from the genetic lesions to the deficit of lysosomal proteins and ensuing tissue pathology, with the ultimate goal to intervene therapeutically. Our line of research in Pompe disease is a traditional example of described activities. The transfer of knowledge to students and society is seen as a rewarding duty. [more]

  100px x 133px_Aida Bertoli Avella

Aida Bertoli-Avella
Our endeavor is the identification and characterization of genes involved in the monogenic forms of congenital heart diseases (CHD) and in familiar aortic aneurysms (AA) aiming at the elucidation of the disease mechanisms.[more]