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Phase I clinical trial unit

Phase I clinical trial unit
It is our goal to improve the care for cancer patients. Therefore we need to develop novel drugs as we still lack the tools to adequately treat our patients. Our unit strives to perform trials with novel agents that could potentially benefit our patients. Within these trials we test novel treatment concepts, such immunotherapy with new drugs, targeted inhibition of molecules involved in cancer and combinations of known and novel drugs. In these trials we determine the dose we can administer to our patients safely and how the new drug is taken up by the body. Increasingly we also try to find early signs of activity of these novel agents, using improved imaging methods and biopsies of tumors.

Phase I academic unit

Information for referring physicans

Information for patients

Information for parties that want to develop novel drugs in collaboration with the Erasmus MC Medical Oncology department

. 2014-04-12_fase 1 groep

Upper row: Dr. F.Eskens, Ms L. van Doorn, Dr. M.Lolkema. Lower row: Ms. D. van der Biessen, Dr. M.de Jonge, Prof.dr. R.Mathijssen

Our Publications

Two key publications
Van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato di Paola E, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S, Nielsen OS; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study.  Lancet. 2001 Oct 27;358(9291):1421-3. PubMed

Steeghs N, Eskens FA, Gelderblom H, Verweij J, Nortier JW, Ouwerkerk J, van Noort C, Mariani M, Spinelli R, Carpinelli P, Laffranchi B, de Jonge MJ. Phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor danusertib in patients with advanced or metastatic solid tumors.  J Clin Oncol. 2009 Oct 20;27(30):5094-101. PubMed 

Two recent publications
van der Biessen DA, Oldenmenger WH, van der Helm PG, Klein D, Oomen-de Hoop E, Mathijssen RH, Lolkema MP, de Jonge MJ.Self-reported quality of life and hope in phase-I trial participants: An observational prospective cohort study.Eur J Cancer Care (Engl). 2018 Sep 4:e12908. doi: 10.1111/ecc.12908.

Von Hoff DD, Rasco DW, Heath EI, Munster PN, Schellens JHM, Isambert N, Tourneau CL, O'Neil B, Mathijssen RHJ, Lopez-Martin JA, Edenfield WJ, Martin M, LoRusso PM, Bray GL, DiMartino J, Nguyen A, Liu K, Laille E, Bendell JC. Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors. Clin Cancer Res. 2018 Sep 1;24(17):4072-4080. doi: 10.1158/1078-0432.CCR-17-3716.