Christopher Schliehe, PhD

Schliehe-51x53px Assistant Professor,
 Department of Immunology

 Email contact: c.schliehe@erasmusmc.nl

 Antigen Presentation and Immune Regulation Research Group  (AIR)

Christopher Schliehe was recruited by the Erasmus MC in 2016 and is currently Assistant Professor in the Department of Immunology. After his doctoral studies at the University of Konstanz, Germany, in which he studied the principles of antigen presentation, he moved to CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, Austria, and investigated mechanisms of immune regulation by epigenetic modifiers as a postdoctoral fellow. His group is focusing on antigen presentation and immune regulation in the context of immunotherapies and aims to identify fundamental processes that might open novel treatment options for patients suffering from immune-related diseases in the future. 

 Group members

Christopher Schliehe, Group leader AIR team summer 2018-300x200
Jane Voerman, Research Assistant
Roos Klop, Research Assistant 
Tim Breugem, MSc Student
Anne Rodenburg, MSc Student

  

     


 
     

 Selected Publications

(See for all publications Schliehe C in PubMed)

Moser S. C., J. S. A. Voerman, D. L. Buckley, G. E. Winter and C. Schliehe.
Acute Pharmacologic Degradation of a Stable Antigen Enhances its Direct Presentation on MHC Class I Molecules.
Frontiers in Immunology 2018, 8:1920. doi: 10.3389/fimmu.2017.01920.

Khamina K., Lercher A., Caldera M., Schliehe C., Vilagos B., Sahin M., Kosack L., Bhattacharya A., Májek P., Stukalov A., Sacco R., James LC., Pinschewer DD., Bennett KL., Menche J., Bergthaler A.
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.
PLoS Pathog. 2017 Dec 20;13(12):e1006758. doi: 10.1371/journal.ppat.1006758. eCollection 2017 Dec.

Kosack L, Gawish R, Lercher A, Vilagos B, Hladik A, Lakovits K, Bhattacharya A, Schliehe C, Mesteri I, Knapp S, and Bergthaler A.
The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.
Scientific Reports 2017, 7: 11289.

Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A.
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
Immunity. 2015 Nov 17;43(5):974-86.

Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A.
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Nat Immunol. 2015 Jan;16(1):67-74.

Schliehe C, Bitzer A, van den Broek M, Groettrup M.
Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo.
J Virol. 2012 Sep;86(18):9782-93.

Schliehe C, Redaelli C, Engelhardt S, Fehlings M, Mueller M, van Rooijen N,Thiry M, Hildner K, Weller H, Groettrup M.
CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo.
J Immunol. 2011 Sep 1;187(5):2112-21.

Schliehe C, Schliehe C, Thiry M, Tromsdorf UI, Hentschel J, Weller H, Groettrup M.
Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy.
J Control Release. 2011 May 10;151(3):278-85.