Marco W.J. Schreurs, PhD

Schreurs-51x53px Medical Immunologist,
 Laboratory Medical Immunology,
 Department of Immunology
 Email contact: m.schreurs@erasmusmc.nl

 Autoimmune Disease Diagnostics (AID) Research interest

Research activities in the AID group focus on biomarkers in autoimmune- and inflammatory disease, in particular autoantibodies. Investigating the role of (novel) autoantibodies in disease processes may result in improved diagnostic and prognostic classification, and improved treatment stratification of such diseases. A second focus is on the role of specific IgE antibodies, in particular IgE directed against allergen components, in allergic disease.

State-of-the-art technology is available in the AID group for the analysis of antibodies in blood, CSF and other body fluids. Technology includes (indirect) immunofluorescence, immunoblotting, ELISA-based techniques and micro-array. In collaboration with different clinical and basic research partners, this technology is used to support different research projects addressing clinical and basic research questions. In addition, currently available antibody detection systems are improved on a regular basis, often in collaboration with the IVD industry, and novel techniques are developed and validated for clinical and research application. Besides investigating the role of known autoantibodies, the AID group also sets out to identify novel autoantibodies.

Fig1-spot-20 Fig2-blot reco

Fig.1 Recoverin-specific anti-retinal autoantibodies in an autoimmune retinopathy patient detected by immunofluorecence (left) and immunoblot (right).

A third focus involves the implementation and application of companion diagnostics for biologic therapy: therapeutic drug monitoring (TDM). TDM for anti-TNF-alpha biologics is currently implemented for the application in both adult and pediatric patients with autoimmune-/inflammatory diseases, in order to investigate the relation between trough biologic levels and different clinical parameters.

Fig3-SLE-10-1500

Fig4-SjS en SSc-10-1500

Fig. 2  Anti-Sm autoantibodies in SLE patients (left) and Sjögren/systemic sclerosis patients (right) analyzed using two different test systems.

The research projects the AID group is currently involved in include:

  1. The role of autoimmunity and involvement of specific anti-retinal autoantibodies in chorioretinal disorders (collaboration with the department of Ophthalmology).
  2. Therapeutic drug monitoring (TDM) assay development and implementation for improving management of patients treated with anti-TNF-alpha biologic therapies (collaboration with the departments of Dermatology and Pharmacy).
  3. The clinical relevance of autoantibodies directed against the voltage-gated potassium channel (VGKC)-complex in patients with (suspected) autoimmune encephalitis (collaboration with the department of Neurology).

 Group members

Marco W.J. Schreurs, Group leader AID aug 2016.300x200
Cindy Kneppers, Research Assistant
Jac Kuijpers-Entrup, Research Assistant
Zenovia Lourens-Florencia,
      Research Assistant
Elham Torabi-Azhandeh,
      Research Assistant
Sanae Boukhrissi, Research Assistant
Jacolien Vermeer, Research Assistant
Kimberly Scheurwater,
      Research Assistant

Associated PhD students:
Josianne ten Berge
      (Dept. Ophthalmology)
Sun-Jine van Bezooijen (Depts. Dermatology and Pharmacy)
Agnes van Sonderen (Dept. Neurology)

 Selected Publications

(Check for all publications: Schreurs MW in Pubmed)

Ten Berge JC, van Rosmalen J, Vermeer J, Hellström C, Lindskog C, Nilsson P, Qundos U, Rothova A, Schreurs MW.
Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy.
PLoS One. 2016 Dec 8;11(12):e0167909.

van Sonderen A, Schreurs MW, Wirtz PW, Sillevis Smitt PA, Titulaer MJ.
From VGKC to LGI1 and Caspr2 encephalitis: The evolution of a disease entity over time.
Autoimmun Rev. 2016 Oct;15(10):970-4.

van Sonderen A, Ariño H, Petit-Pedrol M, Leypoldt F, Körtvélyessy P, Wandinger KP, Lancaster E, Wirtz PW, Schreurs MW, Sillevis Smitt PA, Graus F, Dalmau J, Titulaer MJ.
The clinical spectrum of Caspr2 antibody-associated disease.
Neurology. 2016 Aug 2;87(5):521-8.

van Sonderen A, Thijs RD, Coenders EC, Jiskoot LC, Sanchez E, de Bruijn MA, van Coevorden-Hameete MH, Wirtz PW, Schreurs MW, Sillevis Smitt PA, Titulaer MJ.
Anti-LGI1 encephalitis: Clinical syndrome and long-term follow-up.
Neurology. 2016 Oct 4;87(14):1449-1456.

Rother MB, Schreurs MW, Kroek R, Bartol SJ, van Dongen JJ, van Zelm MC.
The Human Thymus Is Enriched for Autoreactive B Cells.
J Immunol. 2016 Jul 15;197(2):441-8.

van der Valk JP, Schreurs MW, El Bouch R, Arends NJ, de Jong NW.
Mono-sensitisation to peanut component Ara h 6: a case series of five children and literature review.
Eur J Pediatr. 2016 Sep;175(9):1227-34.

van Bezooijen JS, Koch BC, van Doorn MB, Prens EP, van Gelder T, Schreurs MW.
Comparison of Three Assays to Quantify Infliximab, Adalimumab, and Etanercept Serum Concentrations.
Ther Drug Monit. 2016 Aug;38(4):432-8.

Rietveld MJ, Schreurs MW, Gerth van Wijk R, van Daele PL, Hermans MA.
The Basophil Activation Test Is Not a Useful Screening Tool for Hymenoptera Venom-Related Anaphylaxis in Patients with Systemic Mastocytosis.
Int Arch Allergy Immunol. 2016;169(2):125-9.

van Sonderen A, Schreurs MW, de Bruijn MA, Boukhrissi S, Nagtzaam MM, Hulsenboom ES, Enting RH, Thijs RD, Wirtz PW, Sillevis Smitt PA, Titulaer MJ.
The relevance of VGKC positivity in the absence of LGI1 and Caspr2 antibodies.
Neurology. 2016 May 3;86(18):1692-9.

Ten Berge JC, Schreurs MW, Vermeer J, Meester-Smoor MA, Rothova A.
Prevalence and clinical impact of antiretinal antibodies in uveitis.
Acta Ophthalmol. 2016 May;94(3):282-8.

Hoorn EJ, Taams NE, Hurskainen T, Salih M, Weening JJ, Jonkman MF, Pas HH, Schreurs MW.
Bullous Pemphigoid With a Dual Pattern of Glomerular Immune Complex  Disease.
Am J Kidney Dis. 2016 Feb;67(2):302-6.

Hilderink M, Titulaer MJ, Schreurs MW, Keizer K, Bunt JE.
Transient anti-NMDAR encephalitis in a newborn infant due to transplacental transmission.
Neurol Neuroimmunol Neuroinflamm. 2015 Jun 18;2(4):e126.

Dirckx M, Schreurs MW, de Mos M, Stronks DL, Huygen FJ.
The prevalence of autoantibodies in complex regional pain syndrome type I.
Mediators Inflamm. 2015; Epub 2015 Feb 8.

ten Berge JC, Schreurs MW, Dufour-van den Goorbergh BC, de Witte PM, van Schooneveld MJ,
Rothova A.
Severe visual loss caused by autoimmune retinopathy.
Ned Tijdschr Geneeskd. 2015;159:A8039.