Henk Roest




Room Na-615

Email: h.roest@erasmusmc.nl


Henk Roest studied Biology at Leiden University from 1983-1988. He continued his scientific carrier as a graduate student in the department of Plant Molecular Biology, Leiden University, under the supervision of Prof. Ben J.J. Lugtenberg, where he successfully defended his thesis titled “Symbiotic regulation of Rhizobium leguminosarum outer membrane proteins”  (1995). After a one year  interruption, due to social service obligations, he started his first training as a post-doc in the department of Genetics of the Erasmus University Rotterdam where he developed and studied DNA repair mechanisms in mouse models. This period was followed by an NWO funded position at  the department of Endocrinology and Reproduction, Erasmus University, Rotterdam, finishing his scientific training with a KWF funded position as a project leader returning to the department of Genetics.  As of 2003, he is working as a senior scientist in the department of Surgery, Erasmus Medical Center, Rotterdam. Starting in the laboratory of Experimental Surgery, he joined the group of Dr. van der Laan in the Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS) in 2013, where his research activities focus on identification of predictive markers for complications after liver transplantation with an emphasis on microRNAs.



Selected Publications:


Roest HP, Verhoeven CJ, de Haan JE, de Jonge J, IJzermans JN, van der Laan LJ.

Improving Accuracy of Urinary miRNA Quantification in Heparinized Patients Using Heparinase I Digestion.

J Mol Diagn. 2016 Nov;18(6):825-833.


Verhoeven CJ, Farid WR, Roest HP, Ramakrishnaiah V, de Ruiter PE, de Jonge J, Kwekkeboom J, Metselaar HJ, Tilanus HW, Kazemier G, Ijzermans JN, van der Laan LJ.

Polarized release of hepatic microRNAs into bile and serum in response to cellular injury and impaired liver function.

Liver Int. 2016 Jun;36(6):883-92.


Saat TC, Susa D, Roest HP, Kok NF, van den Engel S, Ijzermans JN, de Bruin RW.

A comparison of inflammatory, cytoprotective and injury gene expression profiles in kidneys from brain death and cardiac death donors.

Transplantation. 2014 Jul 15;98(1):15-21.


Bröker ME, Lalmahomed ZS, Roest HP, van Huizen NA, Dekker LJ, Calame W, Verhoef C, Ijzermans JN, Luider TM.

Collagen peptides in urine: a new promising biomarker for the detection of colorectal liver metastases.

PLoS One. 2013 Aug 16;8(8):e70918.


Verweij M, van Ginhoven TM, Mitchell JR, Sluiter W, van den Engel S, Roest HP, Torabi E, Ijzermans JN, Hoeijmakers JH, de Bruin RW.

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration.

Liver Transpl. 2011 Jun;17(6):695-704.


Roest HP, Baarends WM, de Wit J, van Klaveren JW, Wassenaar E, Hoogerbrugge JW, van Cappellen WA, Hoeijmakers JH, Grootegoed JA.

The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.

Mol Cell Biol. 2004 Jun;24(12):5485-95.


Grootegoed JA, Baarends WM, Roest HP, Hoeijmakers JH.

Knockout mouse model and gametogenic failure.

Mol Cell Endocrinol. 1998 Oct 25;145(1-2):161-6. Review.


Roest HP, van Klaveren J, de Wit J, van Gurp CG, Koken MH, Vermey M, van Roijen JH, Hoogerbrugge JW, Vreeburg JT, Baarends WM, Bootsma D, Grootegoed JA, Hoeijmakers JH.

Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

Cell. 1996 Sep 6;86(5):799-810.



Complete list of Pubmed cited publications