Luc van der Laan

Luc

Associate Professor and Head of the Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS).
Room: Na-1006
l.vanderlaan@erasmusmc.nl

Luc van der Laan studied Biology at the University of Amsterdam. After graduation, he started his PhD project under supervisor of Prof. C.D. Dijkstra at the department of Cell Biology and Immunology of the Free University, Amsterdam. After successfully defended his PhD thesis in 1998, he moved to La Jolla, California where he worked for three years as a post-doc fellow in the lab of Prof. D.R. Salomon at The Scripps Research Institute. His research there, funded by the NIH and JDFI, focused on transplantation of human and pig pancreatic islets for diabetes, studying the risks for xenogenic infection by porcine endogenous retroviruses. Hereafter he received a post-doc fellowship from the Dutch Science Organization (NWO) to work at the Sanquin Research Institute in Amsterdam. In 2002 he became staff researcher at the department of Surgery, Erasmus MC-University Medical Center Rotterdam and positioned at the Laboratory of Gastroenterology & Hepatology to continue research on transplantation and viral infections.

Currently he is Associate Professor and Head of the Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS). This laboratory at the department of Surgery established in 2009 accommodates research on tissue injury, infection and regeneration of liver and kidney grafts during organ transplantation. LETIS currently consists of a team of over twenty people. Research is performed in close collaboration with surgeons and clinicians. Dr. van der Laan’s own research team currently consist of two Post-docs, four PhD students, one technician and several under graduates. He trained many undergraduate students and is mentor (co-promoter) of 16 PhD students, of which most already successfully defended.

Dr. van der Laan is councilor of the Dutch Transplantation Society (NTV) and NTV-representative in the Dutch Federation of Biomedical Societies (FEDERA) and serves as committee member of the International Society of Liver Transplantation (ILTS) and Educational Committee of the Erasmus Postgraduate School Molecular Medicine. He served as Associated Editor for Liver Transplantation and is currently on the editorial board of Liver Transplantation, World Journal of Transplantation and ISRN Virology. He has been invited speaker at many International meetings and received several awards including four times the ILTS "Rising Star" mentor/mentee award and five times the NTV “publication of the year” award.

Selected references

  • Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Sasaki N, Boers SJ, Kemperman H, de Jonge J, IJzermans JNM, Niewenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.
    Long-term culture of genome-stable bipotent progenitor cells from adult human liver.
    Cell. 2015 Jan 15;160(1-2):299-312
  • Verhoeven CJ, Farid WR, de Jonge J, Kazemier G, Metselaar HJ, van der Laan LJ 
    Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation.
    J Hepatol. 2014 Sep;61(3):672-84.
  • Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, de Ruiter PE, Willemsen R, Demmers JA, Stalin Raj V, Jenster G, Kwekkeboom J, Tilanus HW, Haagmans BL, Baumert TF and van der Laan LJ.
    Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.
    Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13109-13
  • Verhoeven CJ, Farid WR, de Ruiter PE, Hansen BE, Roest HP, Jonge JD, Kwekkeboom J, Metselaar HJ, Tilanus HW, Kazemier G, van der Laan LJ.
    MicroRNA profiles in graft preservation solution are predictive for ischemic-type biliary lesions after liver transplantation.
    J Hepatol. 2013 Dec;59(6):1231-8.
  • Pan Q, de Ruiter PE, Metselaar HJ, Kwekkeboom J, de Jonge J, Tilanus HW, Janssen HLA and van der Laan LJ.
    Mycophenolic acid augments interferon-stimulated gene expression and inhibits hepatitis C virus infection in vitro and in vivo.
    Hepatology. 2012 Jun;55(6):1673-83
  • Pan Q, Ramakrishnaiah V, Henry SD, Fouraschen S, Kwekkeboom J, Tilanus HW, Janssen HLA and van der Laan LJ. 
    Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNAi
    Gut. 2012 Sep;61(9):1330-9
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