André Boonstra

Andre

Associate Professor
Room: NA-1011
p.a.boonstra@erasmusmc.nl

Professional Experience
André Boonstra studied Biology at the University of Groningen, and did his PhD studies at the department of Immunology of the Erasmus MC in Rotterdam until. He worked the DNAX Research Institute (Palo Alto, USA) as a post-doctoral fellow to study the function of myeloid and plasmacytoid dendritic cells and their effect on Th cell development. He continued his post-doctoral studies at the National Institute for Medical Research Mill Hill (London, UK) on a project focused on immunology of Mycobacterium tuberculosis infections. Since September 2006 he is group leader and staff member at the Department of Gastroenterology and Hepatology of the Erasmus MC (Rotterdam, The Netherlands), and was appointed associate professor in 2012.

As an immunologist on infectious diseases his research is focused on 1) identification of the host factors that determine viral persistence and disease progression, and 2) identification of the factors that determine the outcome of current and novel antiviral treatment strategies. His group currently consists of 3 technicians, 2 post-docs, 3 PhD students and several visiting scientists and undergraduates. The work his research group has extensive expertise on small-animal models, genomics/bio-informatics, and immunology of infectious diseases that are complimentary for the translational studies to understand and predict disease progression and efficacy of antiviral therapy in patients with HBV, HCV and HEV infections.
He contributed to the scientific community by publishing many research papers and several book chapters, and has been member of advisory boards and NIH committees. He received research grants from various pharmaceutical companies, the Dutch government, and from NWO-ZonMW. The research is performed in close collaboration with clinics of the hepatology, infectious diseases and virology units of the Erasmus MC.

 The researchgroup

Selected references

  • Debes JD, van Tilborg M, Groothuismink ZMA, Hansen BE, Schulze zur Wiesch J, von Felden J, de Knegt RJ, Boonstra A.
    Levels of Cytokines in Serum Associate With Development of Hepatocellular Carcinoma in Patients With HCV Infection Treated With Direct-Acting Antivirals.
    Gastroenterology. 2018. Feb; 154(3):515-517.
  • Boeijen LL, Montanari NR, de Groen RA, van Oord GW, van der Heide M, de Knegt RJ, Boonstra A.
    Mucosal-associated invariant T (MAIT) cells are more activated in chronic hepatitis B, but not depleted in blood: reversal by antiviral therapy.
    J Inf Dis. 2017. 216(8):969-976
  • Hou J, Brouwer WP, Kreefft K, Janssen HLA, French PJ, Vanwolleghem T, Boonstra.A.
    Unique liver transcriptomics profiles in chronic hepatitis B: intrinsic intrahepatic functional clusters discriminate distinct clinical phases.
    PlosOne. 2017. 12(6):e0179920.
  • Vanwolleghem T, Boonstra A.
    Focus on the liver: host-virus interactions in HBV.
    J Hepatol. 2017. 66(5):884-885.
  • Debes JD, de Knegt RJ, Boonstra A.
    The path to cancer, and back: Immune modulation during hepatitis C virus infection, progression to fibrosis and cancer, and unexpected roles of new antivirals. Transplantation. 2017. 101(5):910-915.
  • De Groen RA, Hou J, van Oord GW, Groothuismink ZMA, van der Heide M, de Knegt RJ, Boonstra A.
    NK cell phenotypic and functional shifts coincide with specific clinical phases in the natural history of chronic HBV infection.
    Antivir Res. 2017. 140:18-24.
  • Spaan M, Hullegie SJ, Beudeker BJB, Kreefft K, van Oord GW, Groothuismink ZMA, van Tilborg M, Rijnders B, de Knegt RJ, Claassen MAA, Boonstra A.
    Frequencies of circulating MAIT cells are diminished in chronic HCV, HIV and HCV/ HIV co-infection and do not recover during therapy.
    PlosOne. 2016 2016.11(7): e0159243.
  • Schoeman JC, Hou J, Harms AC, Vreeken RJ, Berger R, Hankemeier T, Boonstra A.
    Integrating metabolomics and transcriptomics to characterise the natural progression of chronic hepatitis B.
    Genome Medicine. 2016. 8(1): 64.
  • Van de Garde MDB, Pas SD, van der Net G, Osterhaus ADME, Haagmans BL, Boonstra A, Vanwolleghem T.
    Hepatitis E virus genotype three infection of human liver chimeric mice as a model for chronic HEV infection.
    J Virol. 2016. 90: 4394-4401.
  • Spaan M, van Oord G, Kreefft K, Hou J, Hansen BE, Janssen HLA, de Knegt RJ, Boonstra A.
    Immunological analysis during interferon-free therapy for chronic hepatitis C virus infection reveals modulation of the natural killer cell compartment.
    J Inf Dis. 2016. 213(2): 216-23.
  • Vanwolleghem T, Hou J, van Oord G, Andeweg AC, Osterhaus AD, Pas SD, Janssen HL, Boonstra A.
    Re-evaluation of HBV clinical phases by system biology identifies unappreciated roles for the innate immune response and B cells. 
    Hepatology. 2015 Jul;62(1):87-100.
  • Spaan M, Claassen MA, Hou J, Janssen HL, de Knegt RJ, Boonstra A.
    The Intrahepatic T Cell Compartment Does Not Normalize Years After Therapy-Induced Hepatitis C Virus Eradication.
    J Infect Dis. 2015 Aug 1;212(3):386-90