About our department
Erasmus MC has the largest academic dermatology department in the Netherlands. All the principal investigators combine clinics with research. This combination enables us to identify clinically relevant questions and motivates us to translate the gained research insights back to the patient. This interaction between care and research is the core of the department’s research.
This close relationship implies that we have a strong interest in biobanks of diseases of interest, use routine collected (clinical, pharmacy, claims) data and are involved in many clinical trials (preferably with a laboratory component). We are also involved in the large population based cohorts in Rotterdam (Generation R and Rotterdam Study).
The research methodologies best development in the department are epidemiology (in the broadest sense), clinical research and translational research, especially in immunology and oncology. To achieve a high standard of research, we collaborate in institutional, national and international multidisciplinary consortia and networks. The department is recognized as one of the leading centers for dermato-epidemiology globally.
Basal Cell Carcinoma Follow-Up Study
Energy Based Drug Delivery of Bleomycin in Keloids and Hypertrophic Scars
Epidemiology and genetic epidemiology of skin cancer
Genome-wide Association Studies of-Non-Melanoma-Skin-Cancer
Raman spectroscopy in atopic dermatitis
- Wakkee M, van Egmond S, Louwman M, Bindels P, van der Lei J, Nijsten T, Hollestein L. Opportunities for improving the efficiency of keratinocyte carcinoma care in primary and specialist care: Results from population-based Dutch cohort studies. Eur J Cancer. 2019 Aug;117:32-40.
- van Lee CB, Roorda BM, Wakkee M, Voorham Q, Mooyaart AL, de Vijlder HC, Nijsten T, van den Bos RR. Recurrence rates of cutaneous squamous cell carcinoma of the head and neck after Mohs micrographic surgery vs. standard excision: a retrospective cohort study. Br J Dermatol. 2019 Aug;181(2):338-343.
- Verkouteren JAC, Smedinga H, Steyerberg EW, Hofman A, Nijsten T. Predicting the Risk of a Second Basal Cell Carcinoma. J Invest Dermatol. 2015 Nov;135(11):2649-2656.
- Vossen ARJV, Ardon CB, van der Zee HH, Lubberts E, Prens EP. The anti-inflammatory potency of biologics targeting tumour necrosis factor-α, interleukin (IL)-17A, IL-12/23 and CD20 in hidradenitis suppurativa: an ex vivo study. Br J Dermatol. 2019 Aug;181(2):314-323.
- Kimball AB, Kerdel F, Adams D, Mrowietz U, Gelfand JM, Gniadecki R, Prens EP, Schlessinger J, Zouboulis CC, van der Zee HH, Rosenfeld M, Mulani P, Gu Y, Paulson S, Okun M, Jemec GB. Adalimumab for the treatment of moderate to severe Hidradenitis suppurativa: a parallel randomized trial. Ann Intern Med. 2012 Dec 18;157(12):846-55.
de Wijs LEM, Bosma AL, Erler NS, Hollestein LM, Gerbens LAA, Middelkamp-Hup MA, Kunkeler ACM, Nijsten TEC, Spuls PI, Hijnen DJ. Effectiveness of dupilumab treatment in 95 patients with atopic dermatitis: daily practice data. Br J Dermatol. 2019.
- Totté JEE, Pardo LM, Fieten KB, Vos MC, van den Broek TJ, Schuren FHJ, Pasmans SGMA. Nasal and skin microbiomes are associated with disease severity in paediatric atopic dermatitis. Br J Dermatol. 2019 Oct;181(4):796-804.
- Hu C, Nijsten T, Pasmans SGMA, de Jongste JC, Jansen PW, Duijts L.Associations of eczema phenotypes with emotional and behavioural problems from birth until school age. The Generation R Study. Br J Dermatol. 2019 Dec;181(6):1190-1197
Research line: Oncology
- The genetic consortium on squamous cell carcinoma, involving Decode Iceland, 23andMe (Stanford University) and the Nurse Health Study (Indiana University).
- The international pharmaco-epidemiology Keracon consortium, to study the effects of common drugs on skin cancer development and prevention.
- Public Health England to develop prediction and staging models for SCC.
- The University of Nottingham to collaborate on Raman spectrometry research.
- OCOMEN, an international collaboration initiated by the Erasmus MC for outcome measures on congenital nevi.
- The SKIN European Reference Network.
Research line: Eczema
- We play active roles in the International Society of Atopic Dermatitis (ISAD), the International Eczema Council (IEC) and the EADV Task Force for Atopic Dermatitis (ETFAD) to improve patient care (e.g., the development of new guidelines).
- We work with Sanofi/Regeneron, an international advisory board for children.
- We work with the European Academy of Allergy and Clinical Immunology Task Force Group on High Altitude Treatment.
- We participate in many international, multi-centre, randomized and controlled trials with new biologics (e.g., Abbvie, LEO Pharma, Novartis, UCB and Regeneron).
- We participate in the SKIN European Reference Network for Netherton syndrome and ichthyosis, also in relation to atopy.
- We collaborate with other international cohorts in Generation R.
Research line: Hidradenitis suppurativa
- The Pasteur Institute (Paris, France) and the University of Copenhagen (Denmark) on studies on the microbiome, because of their international expertise in HS and the skin microbiome.
- The University of Michigan's Department of Dermatology on the molecular dissection of HS inflammation.
- The SKIN European Reference Network to study and treat rare syndromic variants of HS in a European collaboration.
- The European Hidradenitis Suppurativa Foundation. This global network of HS specialist centres works with similar databases to facilitate fast and collaborative research.
- The European EADV Task Force for HS, Acne and Rosacea, to study HS in a European collaboration.
- European Guidelines on HS.
- Multiple international, multicentre, randomized and controlled trials with new anti-inflammatory biologics (e.g., Abbvie, InflaRX, Novartis, Janssen and UCB).