Jaap Kwekkeboom

jaapfoto

Associate Professor

Room: Na-1009
j.kwekkeboom@erasmusmc.nl

Jaap Kwekkeboom (1959) studied Medical Biology at the University of Utrecht. During and immediately after his master study he served as a biology teacher at  the Chr. Scholengemeenschap 'De Driestar' in Gouda. In his PhD-study at the Gaubius Institute of the Netherlands Organization for Applied Research (TNO) in Leiden he investigated the regulation of bile acid synthesis in primary hepatocyte cultures. He received his PhD-degree from the University of Leiden in 1990. As a postdoctoral fellow at the departments of Biochemistry and Cell Biology & Histology of the Academic Medical Centre in Amsterdam he investigated mechanisms of B-cell activation and improved technology to generate human monoclonal antibodies. He did a second postdoc at the Sanquin Research Institute in Amsterdam in the field of hematopoietic stem cell transplantation.

In 1997 he was appointed as a scientist by the Department of Internal Medicine II, Erasmus MC,  Rotterdam, to start a new research line on liver transplantation immunology. In 2004 he continued this research line as assistant professor within the Laboratory of Gastroenterology and Hepatology, Erasmus MC. His research group identified immunological, genetic, and viral factors that contribute to the delicate balance between rejection and acceptance of liver grafts. In addition, they studied immunological mechanisms that contribute to the anti-inflammatory properties of high dose intravenous immunoglobulin therapy. In 2017 he was promoted to Associate Professor. His main current research focus is on identification of targets for immunotherapy in gastrointestinal cancers. His research team consists of 6 to 10 members. Under his mentorship 10 PhD-students have successfully defended their thesis.

Dr. Kwekkeboom (co-)authored more than 120  papers in peer-reviewed international scientific journals, and serves as associate editor of the American Journal of Transplantation. He was a Board Member of the Netherlands Society for Hepatology and a core teacher of the Erasmus MC Research Master Infection & Immunity. He teaches in the Bachelor study Clinical Technology and in the Research Master Infection and Immunity, and is a member of the Research Master Examination Committee of Erasmus MC.

Research group

Selected references

  • Zhou G, Sprengers D, Boor PPC, Doukas M, Schutz H, Mancham S, Pedroza-Gonzalez A, Polak WG, de Jonge J, Gaspersz M, Dong H, Thielemans K, Pan Q, IJzermans JNM, Bruno MJ, Kwekkeboom J.
    Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas.
    Gastroenterology 2017;153(4): 1107-1119 e1110.
  • Sideras K, Biermann K, Verheij J, Takkenberg BR, Mancham S, Hansen BE, Schutz HM, de Man RA, Sprengers D, Buschow SI, Verseput MC, Boor PP, Pan Q, van Gulik TM, Terkivatan T, IJzermans JN, Beuers UH, Sleijfer S, Bruno MJ, Kwekkeboom J.
    PD-L1, Galectin-9 and CD8(+) tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma.
    Oncoimmunology 2017;6(2): e1273309.
  • Shi XL, Mancham S, Hansen BE, de Knegt RJ, de Jonge J, van der Laan LJ, Rivadeneira F, Metselaar HJ, Kwekkeboom J.
    Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction.
    J Hepatol 2016;64(6): 1274-1282.
  • Shi XL, de Mare-Bredemeijer EL, Tapirdamaz O, Hansen BE, van Gent R, van Campenhout MJ, Mancham S, Litjens NH, Betjes MG, van der Eijk AA, Xia Q, van der Laan LJ, de Jonge J, Metselaar HJ, Kwekkeboom J.
    CMV Primary Infection Is Associated With Donor-Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation.
    Am J Transplant 2015;15(9): 2431-2442.
  • Tha-In T, Bayry J, Metselaar HJ, Kaveri SV, Kwekkeboom J.
    Modulation of the cellular immune system by intravenous immunoglobulin.
    Trends Immunol 2008;29(12): 608-615.
  • Tha-In T, Metselaar HJ, Tilanus HW, Groothuismink ZM, Kuipers EJ, de Man RA, Kwekkeboom J.
    Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells.
    Blood 2007;110(9): 3253-3262.
  • Tapirdamaz O, Pravica V, Metselaar HJ, Hansen B, Moons L, van Meurs JB, Hutchinson IV, Shaw J, Agarwal K, Adams DH, Day CP, Kwekkeboom J.
    Polymorphisms in the T cell regulatory gene cytotoxic T lymphocyte antigen 4 influence the rate of acute rejection after liver transplantation.
    Gut 2006;55(6): 863-868
  • Boor PP, Metselaar HJ, Mancham S, Tilanus HW, Kusters JG, Kwekkeboom J.
    Prednisolone suppresses the function and promotes apoptosis of plasmacytoid dendritic cells.
    Am J Transplant 2006;6(10): 2332-2341.
  • Kwekkeboom J, Tha-In T, Tra WM, Hop W, Boor PP, Mancham S, Zondervan PE, Vossen AC, Kusters JG, de Man RA, Metselaar HJ.
    Hepatitis B immunoglobulins inhibit dendritic cells and T cells and protect against acute rejection after liver transplantation.
    Am J Transplant 2005;5(10): 2393-2402.

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