Marcel Bijvelds

Marcel Bijvelds

Room NA-615

Marcel Bijvelds studied Biology at the Radboud University, Nijmegen, The Netherlands. At the same institute, he received his PhD for a study of the molecular mechanisms underlying calcium and magnesium transport in intestinal and renal epithelia. Following a postdoctoral training at the Delft University of Technology, he has continued his scientific career at the Department of Biochemistry and, subsequently, the Department of Gastroenterology and Hepatology, of the Erasmus MC. His research is focused on the further elucidation of the signal transduction pathways involved in ion and water transport in gastrointestinal tissues, in health and disease, and on the development of novel therapeutics for diseases characterized by a dysregulation of these pathways, such as infectious diarrhea and cystic fibrosis.

Selected publications

  • Ikpa PT, Sleddens HFBM, Steinbrecher KA, Peppelenbosch MP, De Jonge HR, Smits R, Bijvelds MJC.
    Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.
    Histochem Cell Biol. 2016;146:445-455.
  • Bijvelds MJC, Loos M, Bronsveld I, Hellemans A, Bongartz JP, Ver Donck L, Cox E, De Jonge HR, Schuurkes JA, De Maeyer JH.
    Inhibition of heat-stable toxin-induced intestinal salt and water secretion by a novel class of guanylyl cyclase C inhibitors.
    J Infect Dis. 2015;212:1806-15.
  • Bijvelds MJC, De Jonge HR, Verkade HJ.
    Bile acid handling in cystic fibrosis: marked phenotypic differences between mouse models.
    Gastroenterology 2012;143:e19-20.
  • Dekkers JF, Wiegerinck CL, De Jonge HR, Bronsveld I, Janssens HM, De Winter-de Groot KM, Brandsma AM, De Jong NW, Bijvelds MJC, Scholte BJ, Nieuwenhuis EE, Van den Brink S, Clevers H, Van der Ent CK, Middendorp S, Beekman, JM.
    A functional CFTR assay using primary cystic fibrosis intestinal organoids.
    Nat Med. 2013;19:939-45.
  • Bijvelds MJC, Bot AG, Escher JC, De Jonge HR.
    Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator.
    Gastroenterology. 2009;137:976-85.

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