Diahann Jansen

DiahannDiahann Jansen,
Room Na-1002
E-mail: d.t.s.l.jansen@erasmusmc.nl

Diahann Jansen studied Biomedical Sciences at the Leiden University. During her master degree she studied the application of tolerogenic dendritic cells as an immunotherapy for Type I diabetes in the group of prof. Bart Roep at the Leiden University Medical Center. In 2011 she started her PhD studies under supervision of prof. René Toes at the department of Rheumatology of the Leiden University Medical Center. She focused on the role of the adaptive immune system in the development, treatment and diagnosis of arthritis. She continued investigating the adaptive immune system in rheumatoid arthritis as post doc in the group of prof. Ranjeny Thomas at the University of Queensland Diamantina Institute in Brisbane, Australia in 2015. Here she used MHC class II tetramers to identify self-antigen specific CD4+ T cells in blood of rheumatoid arthritis patients and explored the use of these tetramers to monitor the response to antigen-specific immunotherapy.
In 2017, Diahann continued her scientific career by joining the group of dr. Andrea Woltman at the department of Gastroenterology and Hepatology of the Erasmus MC in Rotterdam. She will work on the development of a therapeutic vaccine against the hepatitis B virus to treat patients with chronic hepatitis B infection. This vaccine will be based on HBV-derived Synthetic Long Peptides (SLP) and Diahann will focus on the selection of optimal SLP-sequences, adjuvant combination and adjuvant-SLP-conjugation.

Selected publications

  • Jansen DT, el Bannoudi H, Arens R, Habets KL, Hameetman M, Huizinga TW, Stoop JN, Toes RE.
    Abatacept decreases disease activity in the absence of CD4(+) T cells in a collagen-induced arthritis model.
    Arthritis Res Ther. 2015 Aug 20;17:220.
  • Jansen DT, van Heemst J, Polydorides S, Moustakas AK, Bax M, Feitsma AL, Bontrop-Elferink DG, Baarse M, van der Woude D, Wolbink GJ, Rispens T, Koning F, de Vries RR, Papadopoulos GK, Archontis G, Huizinga TW, Toes RE.
    Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis.
    Nat Commun. 2015 May 5;6:6681.
  • Jansen DT, Hameetman M, van Bergen J, Huizinga TW, van der Heijde D, Toes RE, van Gaalen FA.
    IL-17-producing CD4+ T cells are increased in early, active axial spondyloarthritis including patients without imaging abnormalities.
    Rheumatology (Oxford). 2015 Apr;54(4):728-35.
  • Kleijwegt FS, Jansen DT, Teeler J, Joosten AM, Laban S, Nikolic T, Roep BO.
    Tolerogenic dendritic cells impede priming of naïve CD8? T cells and deplete memory CD8? T cells.
    Eur J Immunol. 2013 Jan;43(1):85-92.