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Sanne Kloosterboer

KloosterboerAuthor: S.M. (Sanne) Kloosterboer, MSc

PhD project: Safety and Pharmacokinetics of Antipsychotics with autism, SPACE

Promotors: Prof.Dr. B. Dierckx, Dr.B. Koch

Antipsychotic drugs are the cornerstone in the treatment of comorbid behavioral problems in children with autism. Unfortunately, antipsychotics are associated with a broad spectrum of side effects, especially in children. Therapeutic drug monitoring (TDM) of antipsychotics can help to minimize the risk of side effects.
Therefore the SPACe study (Safety and Pharmacokinetics of Antipsychotics in Children with autism) investigates the relation between drug plasma levels and side-effects in children for the three mostly prescribed antipsychotics, risperidone, pipamperone and aripiprazole. A minimally invasive method is used to collect data on drug plasma levels (the Dried Blood Spot  method). A pharmacokinetic and –dynamic safety model is developed in order to reduce side-effects in children.