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Koen Hussaarts

HussaartsAuthor: G.A.M. Hussaarts MSc

PhD project: Drug Interactions in Internal Oncology 2.0

Promotors: Prof. dr. A.H.J. Mathijssen , Prof. dr. T. van Gelder

Co-promotor: Dr. R.W.F. van Leeuwen

Description: Drug interactions potentially can deprive patients from optimal therapy by changing plasma levels and thus drug exposure of certain drugs. My research is about investigating the influence of drug-drug interactions on the pharmacokinetics of anti-cancer agents and practical ways to manage these interactions. For example Tyrosine kinase inhibitors (TKIs) show pH-dependent absorption (exposure decreases rapidly with increasing stomach pH). When erlotinib (a TKI used in lung cancer) is administered with a proton pump inhibitor the exposure decreases with 50%. When erlotinib was administered with coca-cola (an acidic beverage) erlotinib exposure increased with 40% so the interaction was nearly undone.

Publications:

Minor publications:

  • Does (neo)adjuvant or perioperative chemotherapy improve disease-free survival and overall survival in patients with resectable colorectal liver metastasis
    Koen Hussaarts, Kimberly van der Willik, Kees Verhoef
    Minor thesis: Erasmus Journal of medicine: 

Major Publications: 

  • Influence of the Acidic Beverage Cola on the Absorption of Erlotinib in Patients With Non-Small-Cell Lung Cancer
    van Leeuwen RW, Peric R, Hussaarts KG, Kienhuis E, IJzerman NS, de Bruijn P, van der Leest C, Codrington H, Kloover JS, van der Holt B, Aerts JG, van Gelder T, Mathijssen RH.
    J Clin Oncol. 2016 Apr 20;34(12):1309-14. doi: 10.1200/JCO.2015.65.2560. Epub 2016 Feb 8.
  • De invloed van cola op de absorptie van erlotinib bij patiënten met niet-kleincellig longcarcinoom
    N.S. IJzerman, K.G.A.M. Hussaarts, R. Pe  ric, E. Kienhuis, P. de Bruijn, C. van der Leest, H. Codrington, J.S. Kloover, B. van der Holt, J.G. Aerts, T. van Gelder, R.W.F. van Leeuwen en R.H.J. Mathijssen
    Nederlands Tijdschrift voor Oncologie, Jaargang 13, nr 7. November 2016
  • Factors Affecting the Association of Proton Pump Inhibitors and Capecitabine Efficacy in Advanced Gastroesophageal Cancer.
    Hussaarts KGAM, van Leeuwen RWF, Mathijssen RHJ.
    JAMA Oncol. 2018 Feb 1;4(2):263-264. doi: 10.1001/jamaoncol.2016.7019.