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Femke de Velde

de-veldeAuthor: Drs. Femke de Velde

PhD project:
Using PK/PD to optimize dosing of beta-lactam antibiotics

prof. dr. J.W. Mouton (department of Medical Microbiology and Infectious Diseases) and prof. T. van Gelder (department of Hospital Pharmacy and department of Internal Medicine)

dr. B.C.P. Koch (department of Hospital Pharmacy)

In an era of increasing antimicrobial resistance and with few new drugs making it to the market, antibiotic use must be optimized in order to improve clinical outcomes of infections. This PhD project includes the development of population pharmacokinetic (PK) models for several beta-lactam antibiotics to investigate the exposure and variability in the population. The population PK models are used to perform Monte Carlo simulations with the objective to evaluate the probability of pharmacodynamic (PD) target attainment of several dosing regimens. The second objective of the PhD project is to compare parametric and nonparametric population PK modelling approaches.