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Florine Berger

BergerAuthor:  F.A. (Florine) Berger, Msc

PhD project: Drug-induced QT prolongation

Promotors: Prof. Dr. T. van Gelder; Prof. dr. P.M.L.A. van den Bemt

Description:
At this moment, for over 50 drugs have been shown to cause QTc prolongation, which is a serious risk factor for ventricular arrhythmias and sudden cardiac death. The risk might increase when such drugs are combined. However, the exact magnitude of the problem is unknown making it difficult for health care professionals to interpret these drug-drug interactions. Therefore, the aim of this PhD project is to provide guidance on safe prescription practices by gaining more insight into the prevalence and associated risk factors of QT prolongation in patients using QTc-prolonging drugs.

Publications: 

  • Ciprofloxacin as a QTc prolonging drug in the G-Standaard: Processing of the interaction signal in practice.
    Woldman E, Berger FA, Van Den Bemt P, Van Den Hoeven R, Becker M. (2016) Pharm Weekbl 151 (50): 25-29
  • Media attention regarding sudden cardiac death associated with domperidone use does not affect in hospital ECG recording.
    Berger FA, Saaid S, van Gelder T, Stricker B, Becker M, van den Bemt P.
    (2017) Pharmacoepidemiology and Drug Safety 26 (11): 1418-1424
  • QTc prolongation during ciprofloxacin and fluconazole combination therapy: Prevalence and associated risk factors.
    Berger FA, Monadian N, de Groot NMS, Santbergen B, van der Sijs H, Becker ML, Broers AEC, van Gelder T, van den Bemt PMLA.
    (2017) Br J Clin Pharmacol 84 (2): 369-378
  • Risk factors for QTc interval prolongation.
    Heemskerk CPM, Pereboom M, van Stralen K, Berger FA, van den Bemt P, Kuijper AFM, van der Hoeven RTM, Mantel-Teeuwisse AK, Becker ML.
    (2018) Eur J Clin Pharmacol 74 (2): 183-191
  • Development and validation of a Risk Score Model to support the handling of QT drug-drug interactions.
    Berger FA, van der Sijs IH, van Gelder T, van den Bemt PMLA.
    (2018) Eur J Clin Pharmacol – Submitted
  • Development and validation of a model to predict QTc interval prolongation in patients using QTc-prolonging drugs.
    Nayana A, Rolvink J, Berger FA, van den Bemt PMLA, Kuijper AFM, van der Hoeven RTM, Becker ML.
    (2018) Int J Clin Pharm – Submitted