Marteijn, Jurgen

Jurgen Marteijn

Marteijn_200Jurgen A. Marteijn received his Ph.D. from the Radboud University in Nijmegen, The Netherlands, in 2007. The PhD work focused on the role of the ubiquitin proteasome system during blood cell differentiation. Currently, he is an assistant professor at the Department of Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands. The central theme of his research is how the complex UV-induced DNA damage response (UV-DDR), including DNA-repair, is regulated by post-translational modifications or protein-protein interactions in the context of chromatin. Using different live-cell microscopy techniques and state-of-the-art proteomics approaches we search for novel regulators of the UV-DDR with special interest in the ubiquitin proteasome system and proteins involved in chromatin biology.

Jurgen is a lecturer of the Genetics course for the Bsc. Nanobiology and received Veni, Horizon, Vidi and Erasmus MC personal fellowships.

Selected Papers:
1: Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH.
Understanding nucleotide excision repair and its roles in cancer and ageing.
Nat Rev Mol Cell Biol. 2014 Jul;15(7):465-81.

2: Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W and Marteijn JA
Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage
Molecular Cell, 2013 August 23.

3: Mattiroli F, Vissers JHA, van Dijk WJ, Ikpa P,  Citterio E, Vermeulen W, Marteijn JA and Sixma1 TK RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
Cell 2012 Sep 14.

4: Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA.
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
Nature Genetics. (2012) 44(5):598-602.

5: Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
Journal of Cell Biology. 2009 186(6):835-47.