Jenster, Guido

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Guido Jenster received his PhD on mapping of the functional domains of the human androgen receptor. As a postdoctoral associate at Baylor College of Medicine, Houston, he worked on the newly identified steroid receptor coactivators. As an Assistant Professor of Urology at the University of Texas M.D. Anderson Cancer Center, Houston and the Department of Urology at Erasmus MC, he started his work on the role of the androgen receptor in prostate cancer.


In recent years, the research focus has been extended with:

  • the identification and characterization of prostate cancer (PCa) initiating (stem) cells
  • the discovery and analysis of (novel) genes and pathways that contribute to cancer progression using exon and SNP microarrays and next-generation sequencing
  • the identification of novel biomarkers for prostate cancer using the latest mass spectrometry techniques


Jenster group webpage


Key publications

Jansen FH, Krijgsveld J, van Rijswijk A, van den Bemd GJ, van den Berg MS, van Weerden WM, Willemsen R, Dekker LJ, Luider TM, Jenster G (2009)
Exosomal secretion of cytoplasmic prostate cancer xenograft-derived proteins.
Mol Cell Proteomics 8:1192-1205

Hermans KG, Bressers AA, van der Korput HA, Dits NF, Jenster G, Trapman J (2008)
Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer.
Cancer Research 68:3094-3098 

Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G (2006)
Evolution of the androgen receptor pathway during progression of prostate cancer
Cancer Research 66:5012-5020  

Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai M-J and O’Malley BW (1997)
Steroid receptor coactivator one is a histone acetyltransferase
Nature 389:194-198