Gent, Dik van

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Dr Dik van GentDik van Gent received his PhD in Biology from the Free University Amsterdam on the basis of a research project conducted at the Netherlands Cancer Institute on the Human Immunodeficiency Virus Integrase protein. He did his postdoctoral training at the National Institutes of Health and developed an in vitro system to study V(D)J recombination. He currently studies the Non-homologous End-joining pathway of DNA double-strand break repair. He is mainly interested in the mechanism of Non-homologous end-joining, and how different pathways of DNA double-strand break repair collaborate to counteract DNA damage to survive radiation damage and to prevent tumorigenesis.

As of September 2013, Dik van Gent is program director of the MSc Molecular Medicine program at Erasmus MC.


Van Gent group page


Key publications

Van der Burg M, IJspeert H, Verkaik NS, Turul T, Wiegant WW, Morotomi-Yano K, Mari PO, Tezcan I, Chen DJ, Zdzienicka MZ, van Dongen JJM, and van Gent DC (2009)
DNA-PKcs Mutation In a T-B-SCID Patient Inhibits Artemis Activation and Non-Homologous End-Joining
J Clin Invest 119:91-98

Weterings E, Verkaik NS, Keijzers G, Florea BI, Wang SY, Ortega LG, Uematsu N, Chen DJ and van Gent DC (2009)
The Ku80 carboxy-terminus stimulates Joining and Artemis-mediated processing of DNA ends
Mol Cell Biol 29:1134-1142

Pothof J, Verkaik NS, van IJcken W, Wiemer EAC, Ta VTB, van der Horst GTJ, Jaspers NGJ, van Gent DC, Hoeijmakers JHJ, and Persengiev SP (2009)
MicroRNA-mediated Gene Silencing Modulates the UV-induced DNA Damage Response
EMBO J 28:2090-2099

Pothof J, Verkaik NS, Hoeijmakers JHJ, and van Gent DC (2009)
MicroRNA responses and stress granule formation modulate the DNA damage response
Cell Cycle 8:3462-3468

Van Gent DC and van der Burg M (2007)
Non-Homologous End-Joining, a Sticky Affair
Oncogene, 26, 7731-7740

Mari PO, Florea BI, Persengiev SP, Verkaik NS, Brüggenwirth HT, Modesti MM, Giglia-Mari G, Bezstarosti K, Demmers JAA, Luider TM, Houtsmuller AB and van Gent DC (2006)
Dynamic Assembly of End-joining Complexes Requires Interaction between Ku70/80 and XRCC4
PNAS USA, 103, 18597-18602

van Gent DC, Hoeijmakers JHJ, and Kanaar R (2001)
Chromosomal stability and the DNA double-stranded break connection
Nat Rev Genet 2:196-206