Project 8

Hypertension, the kidney and vascular ageing: focus on the renin-angiotensin-aldosterone system

This project focuses on hypertension, capitalizing on four pathways to discover novel intervention pathways, namely:
- the role of aldosterone in difficult-to-treat hypertensive subjects,
- hypertension induced by angiogenesis inhibition in patients with cancer,
- the impact of genomic instability on hypertension, and vascular and renal function, and
- the regulation of volume and osmoregulation in kidneys by WNKs and exosomes

An important unifying aspect in all the above topics, apart from the common relationship with hypertension, is the involvement of the renin-angiotensin-aldosterone system (RAAS), resulting in projects that investigate angiotensin/aldosterone interaction in the kidney, the function of the (pro)renin receptor in intercalated cells, the vasodilator effects of endothelial angiotensin II type 2 receptors (with an emphasis on gender-related aspects), the angiotensin-(1-7) / Mas receptor axis, the non-genomic effects of aldosterone in the vessel wall, and the role of RAAS- and related interventions on genomic instability-related vascular and renal dysfunction. The studies concerning genomic instability involve transgenic mice with  decreased DNA repair function, and are performed in close collaboration with the Departments of Genetics and of Vascular Surgery. Studies on the importance of nucleotide phosphodiesterases in ageing occur in collaboration with the Department of Epidemiology. 

Principal InvestigatorsAHJ Danser, EJ Hoorn, AH van den Meiracker, AJM Roks, 
R Zietse
Co-InvestigatorsDJGM Duncker, J Essers, OH Franco, JHJ Hoeijmakers, K Mirabito,
MA de Raaf, IKM Reiss, SHP Simons
PhD candidatesAD Moes, L Saleh, D Severs, M. Glisic, D. Bovee, M van den Heuvel, E. Hitzerd, R Neuman, E uijl, E Portilla Fernandez, E Ataei, K Golshiri