Project 28

Surgery for congenital heart disease

Surgical management of congenital heart disease has improved significantly in the last decades and has resulted in improved survival into adulthood. Thus the number of adult patients is growing. While the number of patients to be operated at young age is more or less constant, the number of patients needing an operation at adult age is increasing, both the number of primary operations as well as the number of reoperations due to residual cardiac abnormalities. In particular, an abnormal load is commonly imposed on the right ventricle or on single ventricular hearts. Residual abnormalities may cause heart failure, rhythm disturbances and may affect quality of life. Evidence-based treatment is often lacking. Guidelines for timing of catheter intervention and surgical therapy also may lack sufficient evidence. This project aims at outcome research with emphasis on assessment of cardiac function in the right ventricle and in structurally abnormal hearts with conventional imaging techniques. An important part of this theme concerns these imaging techniques on one hand and improvement of clinical decision-making and therapy on the other.

Principal InvestigatorsAJJC Bogers
Co-InvestigatorsWA Helbing, JW Roos-Hesselink, JJM Takkenberg
PhD candidatesJRG Etnel, A van Saet, PC vd Woestijne, GA Zeilmaker-Roest, JLR Romeo