Project 12

Cardiovascular genetics and metabolic diseases

At the Erasmus outpatient clinic for cardiovascular genetics, family based approaches are employed to study inherited cardiovascular diseases: cardiomyopathies, congenital heart malformations, arrhythmias, dyslipidemias, diabetes mellitus, hypertension and severe premature coronary artery disease.
Technical innovation is a hall mark of this research: for example, multidimensional omics and novel imaging modalities are used to identify new phenotypes to identify modifier genes in addition to major locus effects.

We have identified a large number of novel genes that are associated with cardiovascular disease and related traits. In addition, we perform molecular and biochemical studies to get a better understanding of the mechanisms underlying the diseases and the complications.
Our clinical research is performed in patients with very rare diseases, like ?-myosin heavy chain defects in noncompaction cardiomyopathy, but also more common disorders of synthesis and processing of insulin in families with type 2 diabetes.

Principal InvestigatorsEJG Sijbrands, F Zijlstra
Co-InvestigatorsC.M. van Duijn, F.U.S. Mattace Raso, M. Michels,  M.T. Mulder, E.C.H. Friesema, J.G. Langendonk, M. van Hoek, J.E. Roeters van Lennep, JW Roos-Hesselink, A.F.L. Schinkel, A.G. Uitterlinden, A.J.M. Verhoeven, M.W. Wessels
PhD candidates

D Bolignano, S Bos, TTW van Herpt, SM den Hoedt, S Jainandunsing, RFH Lemmers, M Licona-Rashid, RA Neeleman, B Özcan, SM Snelder, B Spoto, HG van Velzen, R Vongpromek, PA Vriesendorp, R Yahya, SS Badal, D. Wensink