Project 11

Percutaneous interventions in structural heart disease

Catheter-based treatment of structural heart disease is an innovative and rapidly evolving treatment modality. At present it is primarily reserved for patients with aortic stenosis and is expected to become the default treatment strategy. As a result of ongoing innovation in catheter technology, bioprosthetic materials (scaffolding frame and tissue), imaging (3-4D, co-registration) in addition to experience with catheter-based treatment (patient selection, treatment and follow-up), patients with mitral and tricuspid pathology are expected to be treated with and benefit from catheter-based treatment.
Research in this domain includes predominantly clinical cohort research examining the safety and efficacy, the evaluation of responder and non-responder of existing and newly introduced catheter-based treatments in addition to the assessment of pathophysiologic effects of treatment. Also, patient-specific computer simulation is expected to play an increasing role in treatment planning by forecasting valve function before actual valve implantation. The department of cardiology of the Erasmus MC has a long-standing tradition of collaborating with biomedical engineers in this field.

Principal InvestigatorsPPT de Jaegere, JJM Takkenberg
Co-InvestigatorsMJ Lenzen, NMDA Van Mieghem, RPK Budde, FUS Mattace Raso, YJHJ Teverne, HJM Verhagen
PhD candidatesN El Faquir, L van Gils, JA Goudzwaard, Z Rahhab, MJAG de Ronde-Tillmans