Lifestyle studies

Although highly underrated during the last century, the effects of patient’s lifestyle on drug exposure and toxicity is enormous. At first, we became aware of the devastating effects of certain complementary and alternative medicine (CAM; i.e. St. John’s wort) on systemic drug concentrations of anti-cancer agents (i.e. irinotecan, imatinib, docetaxel); then comparable effects of smoking (i.e. erlotinib, irinotecan) were published. But also the use of alcohol, a high-fat meal, grapefruit(juice), time of the day taking anti-cancer medication, and adherence may (potentially) all affect the exposure to a drug or influence the number and/or severity of side effects. Recently, also the (positive) role of cola on the absorption of erlotinib was proven. (Van Leeuwen et al., J Clin Oncol 2016)

 

    Lisette ESMO 2014 resize

  Lisette Binkhorst with her poster on the switch of SSRIs in tamoxifen using patients (ESMO, Madrid 2014)

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Media-attention involving the erlotinib-cola study as presented at ESMO, Vienna 2015.