Hanan El Marroun

Hanan El Marroun
post-doc researcher

Tel: +31 (0) 10-7034275 
Email  h.marrounel@erasmusmc.nl

Erasmus MC-Sophia
Department of Child and Adolescent Psychiatry/Psychology
Wytemaweg 8 - KP2, 3015 CN Rotterdam  
PO Box 2060 - KP2, 3000 CB Roterdam

I am a post-doc researcher with research experience in prenatal exposure to cannabis and child development. During my PhD project I examined determinants of maternal cannabis use during pregnancy, and long-term effects of prenatal exposure on child development.

Currently my project is concerned with prenatal exposure to antidepressants and tranquilizers, including selective serotonin reuptake inhibitors (SSRI’s) and benzodiazepines, in relation to child development. Child development, in these studies, comprises foetal growth, infant behaviour and child cognition. In addition, we also assess brain images of the children at age 6-7 yrs to determine possible effects of prenatal exposure to cannabis and/or tobacco, and prenatal exposure to antidepressants by using a Magnetic Resonance Imaging (MRI) procedure. Therefore, the focus of my research in the coming years will be specifically orientated towards neuroscience and brain development.

- The Generation R Study

Research Interests: 
- Prenatal substance use
- Prenatal use of psychotropic medication
- Foetal development (growth, brain growth)
- Child development (behaviour and cognitive development)
- Structural and functional brain development

1: El Marroun H, White TJ, van der Knaap NJ, Homberg JR, Fernández G, Schoemaker
NK, Jaddoe VW, Hofman A, Verhulst FC, Hudziak JJ, Stricker BH, Tiemeier H.
Prenatal exposure to selective serotonin reuptake inhibitors and social
responsiveness symptoms of autism: population-based study of young children. Br J
Psychiatry. 2014 Aug;205(2):95-102. doi: 10.1192/bjp.bp.113.127746. Epub 2014 Aug
1. PubMed PMID: 25252317.

2: Mous SE, Muetzel RL, El Marroun H, Polderman TJ, van der Lugt A, Jaddoe VW,
Hofman A, Verhulst FC, Tiemeier H, Posthuma D, White T. Cortical thickness and
inattention/hyperactivity symptoms in young children: a population-based study.
Psychol Med. 2014 Nov;44(15):3203-13. doi: 10.1017/S0033291714000877. Epub 2014
Jul 17. PubMed PMID: 25065362.

3: van der Knaap NJ, El Marroun H, Klumpers F, Mous SE, Jaddoe VW, Hofman A,
Homberg JR, White T, Tiemeier H, Fernández G. Beyond classical inheritance: the
influence of maternal genotype upon child's brain morphology and behavior. J
Neurosci. 2014 Jul 16;34(29):9516-21. doi: 10.1523/JNEUROSCI.0505-14.2014. PubMed
PMID: 25031395.

4: El Marroun H, White T, Verhulst FC, Tiemeier H. Maternal use of antidepressant
or anxiolytic medication during pregnancy and childhood neurodevelopmental
outcomes: a systematic review. Eur Child Adolesc Psychiatry. 2014
Oct;23(10):973-92. doi: 10.1007/s00787-014-0558-3. Epub 2014 May 27. PubMed PMID:

5: Ghassabian A, El Marroun H, Peeters RP, Jaddoe VW, Hofman A, Verhulst FC,
Tiemeier H, White T. Downstream effects of maternal hypothyroxinemia in early
pregnancy: nonverbal IQ and brain morphology in school-age children. J Clin
Endocrinol Metab. 2014 Jul;99(7):2383-90. doi: 10.1210/jc.2013-4281. Epub 2014
Mar 31. PubMed PMID: 24684462.

6: El Marroun H, Schmidt MN, Franken IH, Jaddoe VW, Hofman A, van der Lugt A,
Verhulst FC, Tiemeier H, White T. Prenatal tobacco exposure and brain morphology:
a prospective study in young children. Neuropsychopharmacology. 2014
Mar;39(4):792-800. doi: 10.1038/npp.2013.273. Epub 2013 Oct 7. PubMed PMID:
24096296; PubMed Central PMCID: PMC3924517.

7: Elfrink ME, Moll HA, Kiefte-de Jong JC, El Marroun H, Jaddoe VW, Hofman A,
Stricker BH, ten Cate JM, Veerkamp JS. Is maternal use of medicines during
pregnancy associated with deciduous molar hypomineralisation in the offspring? A
prospective, population-based study. Drug Saf. 2013 Aug;36(8):627-33. doi:
10.1007/s40264-013-0078-y. PubMed PMID: 23743695.

8: White T, El Marroun H, Nijs I, Schmidt M, van der Lugt A, Wielopolki PA,
Jaddoe VW, Hofman A, Krestin GP, Tiemeier H, Verhulst FC. Pediatric
population-based neuroimaging and the Generation R Study: the intersection of
developmental neuroscience and epidemiology. Eur J Epidemiol. 2013
Jan;28(1):99-111. doi: 10.1007/s10654-013-9768-0. Epub 2013 Jan 26. PubMed PMID:

9: van den Bosch GE, El Marroun H, Schmidt MN, Tibboel D, Manoach DS, Calhoun VD,
White TJ. Brain connectivity during verbal working memory in children and
adolescents. Hum Brain Mapp. 2014 Feb;35(2):698-711. doi: 10.1002/hbm.22193. Epub
2012 Dec 11. PubMed PMID: 23233279.

10: van Mil NH, Steegers-Theunissen RP, Bongers-Schokking JJ, El Marroun H,
Ghassabian A, Hofman A, Jaddoe VW, Visser TJ, Verhulst FC, de Rijke YB, Steegers
EA, Tiemeier H. Maternal hypothyroxinemia during pregnancy and growth of the
fetal and infant head. Reprod Sci. 2012 Dec;19(12):1315-22. doi:
10.1177/1933719112450338. Epub 2012 Aug 9. PubMed PMID: 22878528.

11: El Marroun H, Zeegers M, Steegers EA, van der Ende J, Schenk JJ, Hofman A,
Jaddoe VW, Verhulst FC, Tiemeier H. Post-term birth and the risk of behavioural
and emotional problems in early childhood. Int J Epidemiol. 2012
Jun;41(3):773-81. doi: 10.1093/ije/dys043. Epub 2012 May 2. PubMed PMID:

12: El Marroun H, Jaddoe VW, Hudziak JJ, Roza SJ, Steegers EA, Hofman A, Verhulst
FC, White TJ, Stricker BH, Tiemeier H. Maternal use of selective serotonin
reuptake inhibitors, fetal growth, and risk of adverse birth outcomes. Arch Gen
Psychiatry. 2012 Jul;69(7):706-14. doi: 10.1001/archgenpsychiatry.2011.2333.
PubMed PMID: 22393202.

13: El Marroun H, Hudziak JJ, Tiemeier H, Creemers H, Steegers EA, Jaddoe VW,
Hofman A, Verhulst FC, van den Brink W, Huizink AC. Intrauterine cannabis
exposure leads to more aggressive behavior and attention problems in 18-month-old
girls. Drug Alcohol Depend. 2011 Nov 1;118(2-3):470-4. doi:
10.1016/j.drugalcdep.2011.03.004. Epub 2011 Apr 5. PubMed PMID: 21470799.

14: Geelhoed JJ, El Marroun H, Verburg BO, van Osch-Gevers L, Hofman A, Huizink
AC, Moll HA, Verhulst FC, Helbing WA, Steegers EA, Jaddoe VW. Maternal smoking
during pregnancy, fetal arterial resistance adaptations and cardiovascular
function in childhood. BJOG. 2011 May;118(6):755-62. doi:
10.1111/j.1471-0528.2011.02900.x. Epub 2011 Mar 8. PubMed PMID: 21385303.

15: El Marroun H, Tiemeier H, Jaddoe VW, Hofman A, Verhulst FC, van den Brink W,
Huizink AC. Agreement between maternal cannabis use during pregnancy according to
self-report and urinalysis in a population-based cohort: the Generation R Study.
Eur Addict Res. 2011;17(1):37-43. doi: 10.1159/000320550. Epub 2010 Oct 26.
PubMed PMID: 20975275.

16: El Marroun H, Tiemeier H, Steegers EA, Roos-Hesselink JW, Jaddoe VW, Hofman
A, Verhulst FC, van den Brink W, Huizink AC. A prospective study on intrauterine
cannabis exposure and fetal blood flow. Early Hum Dev. 2010 Apr;86(4):231-6. doi:
10.1016/j.earlhumdev.2010.03.006. Epub 2010 May 6. PubMed PMID: 20451334.

17: El Marroun H, Tiemeier H, Steegers EA, Jaddoe VW, Hofman A, Verhulst FC, van
den Brink W, Huizink AC. Intrauterine cannabis exposure affects fetal growth
trajectories: the Generation R Study. J Am Acad Child Adolesc Psychiatry. 2009
Dec;48(12):1173-81. doi: 10.1097/CHI.0b013e3181bfa8ee. PubMed PMID: 19858757.

18: El Marroun H, Tiemeier H, Jaddoe VW, Hofman A, Mackenbach JP, Steegers EA,
Verhulst FC, van den Brink W, Huizink AC. Demographic, emotional and social
determinants of cannabis use in early pregnancy: the Generation R study. Drug
Alcohol Depend. 2008 Dec 1;98(3):218-26. doi: 10.1016/j.drugalcdep.2008.05.010.
Epub 2008 Jul 7. PubMed PMID: 18606505.