Publications Rebekka Schneider-Kramann

Selection

SELECTED PUBLICATIONS (or link to pubmed - search Rebekka Schneider)

2017:

  • Schneider, R. K. #, Mullally, A., Dugourd, A., Peisker, F., Hoogenboezem, R., van Strien, P. M., Bindels, E. M., Heckl, D., Büsche, G., Fleck, D., Müller-Newen, G., Wongboonsin, J., Ventura Ferreira, M., Puelles, V. G., Saez-Rodriguez, J., Ebert, B. L., Humphreys, B. D., Kramann, R.#. (2017): Gli1+ mesenchymal stromal cells are a key driver of bone marrow fibrosis and an important cellular therapeutic target. Cell Stem Cell, in press. #corresponding author

2016:

  • Kramann, R.,# Goettsch, C., Wongboonsin, J., Iwata, H., Schneider, R. K., Kuppe, C., Kaesler, N., Chang-Panesso, M., Machado, F. G., Gratwohl, S., Madhurima, K., Hutcheson, J. D., Jain, S., Aikawa, E., Humphreys, B. D. (2016): Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease. Cell Stem Cell, 19, 628-642. #corresponding author
  • Schneider R.K., Schenone M., Ventura Ferreira M., Kramann R., Joyce C.E., Hartigan C., Beier F., Brümmendorf T.H., Germing U., Platzbecker U., Buesche G., Knuechel R., Chen M.C., Waters C.S., Chen E., Chu L.P., Novina C., Lindsley R.C., Carr S.A., Ebert B.L. (2016): Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8/S100A9 (2016)  Nature Medicine, 22, 288-297
  • Obeng EA, Chappell RJ, Seiler M, Chen MC, Campagna D, Schmidt PJ, Schneider RK,  Yu L, Lord AM, McConkey ME, Ali AM, Raza A, Buonamici S, Smith PG, Mullally A, Wu CJ, Fleming MD and Ebert BL. Physiologic expression of Sfb1K700E causes impaired erythropoiesis, aberrant splicing, and sensitivity to a spliceosome inhibitor. Cancer Cell. 2016 Sep 12;30(3):404-17.
  • Elf S, Abdelfattah N, Chen E, Perales-Patón J, Rosen E, Ko A, Peisker F, Florescu N, Giannini S, Wolach O, Morgan E, Losman JA, Schneider RK, Al-Shahrour F, Mullally A. Mutant calreticulin requires both its mutant C-terminus and the thrombopoietin receptor for oncogenic transformation. Cancer Discovery, 2016 Apr;6(4):368-81.
  • Puram RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M, Tothova Z, Tejero H, Heckl D, Järås M, Chen M, Li H, Tamayo A, Cowley GS, Rozenblatt-Rosen O, Al-Shahrour F, Regev A, Ebert BL. Core circadian clock genes regulate leukemia stem cells in AML. Cell. 2016 Apr 7;165(2):303-16.
  • Ventura Ferreira MS, Bergmann C, Bodensik I, Peukert K, Abert J, Kramann, R, Kachel, P, Rath B, Rütten S, Knuchel R, Ebert BL, Fischer H, Brümmendorf T, Schneider RK. An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites. Journal of Hematology and Oncology, 2016 Jan 25;9:4.

2015:

  • Kowalczyk MS, Tirosh I, Heckl D, Nageswara Rao T, Dixit A, Haas BJ, Schneider RK, Wagers AJ, Ebert BL, Regev A. Single cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res. 2015 Oct 1
  • Beier F, Masouleh BK, Buesche G, Ventura Ferreira MS, Schneider RK, Ziegler P, Wilop S, Vankann L, Gattermann N, Platzbecker U, Giagounidis A, Götze KS, Nolte F, Hofmann WK, Haase D, Kreipe H, Panse J, Blasco MA, Germing U, Brümmendorf TH. Telomere dynamics in patients with del (5q) MDS before and under treatment with lenalidomide. Leukemia Research. 2015 Sep 21. pii: S0145-2126(15)30380-5.  
  • Krönke J*, Fink EC*, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND,  Chamberlain PP, Mani DR,  Wah Man H, Gandhi AK, Svinkina T, Schneider RK, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers BE, Carr SA, Chopra R, and Ebert BL. Lenalidomide induces ubiquitination and degradation of CK1? in del(5q) MDS. Nature. 2015 July 9;523(7559):183-8.
  • Ugrankar R, Berglund E, Akdemir F, Tran C, Soo Kim M, Noh J, Schneider RK, Ebert B, Graff JM. Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism. Nature Communications. 2015 May 21;6:7102.
  • Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf M, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD Pharmacological Gli2 Inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis, J Clin Invest 2015 in press (scheduled for online publication on July 20th 2015)

2014:

  • Schneider RK, Ademà V, Heckl D, Järås M, Mallo M, Lord AM, Chu LP, McConkey ME, Kramann R, Mullally A, Bejar R, Solé F, Ebert BL. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer Cell. 2014 Oct 13;26(4):509-20.
  • Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie PA, Henderson JM, Ebert BL and Humphreys BD. Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis. Cell Stem Cell. November 2014.
  • Schneider RK, Ziegler S, Leisten I, Ferreira MSV, Schumacher A, Rath B, Fahrenkamp D, Muller-Newen G, Crysandt M, Wilop S, Jost E, Koschmieder S, Knuchel R, Brummendorf TH, Ziegler P. Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms. Journal of Hematology and Oncology. In press, December 2014.
  • Chen E, Schneider RK, Breyfogle LJ, Rosen EA, Poveromo L, Elf S, Ko A, Brumme K, Levine R, Ebert BL, Mullally A. Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms. Blood. 2014 (in press).
  • Järås M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. Journal of Experimental Medicine. 2014 Apr 7;211(4):605-12.
  • De Vita S, Schneider RK, Garcia M, Wood J, Gavillet M, Ebert BL, Gerbaulet A, Roers A, Levine RL, Mullally A, Williams DA. Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis. PLoS One. 2014 May 2;9(5).
  • Kramann R, Erpenbeck J, Schneider RK, Röhl AB, Hein M, Brandenburg VM, van Diepen M, Marx N, Floege J, Schlieper G. Speckle Tracking Echocardiography Detects Uremic Cardiomyopathy Early and Predicts Cardiovascular Mortality in ESRD. Journal of the American Society of Nephrology. 2014 Apr 3.
  • Qin J, Sontag S, Lin Q, Mitzka S, Leisten I, Schneider RK, Wang X, Jauch A, Peitz M, Brüstle O, Wagner W, Zhao RC, Zenke M. Cell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells and Development. 2014 Aug 11

2013

  • Losman JA, Looper R, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley G, Root D, Ebert BL, Kaelin WG Jr. (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible. Science. 2013, March 29;339(6127):1621-5.
  • Kramann R, Kunter U, Brandenburg VM, Leisten I, Ehling J, Klinkhammer B, Knüchel R, Floege J and Schneider RK. Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease. Journal of Bone and Mineral Research. 2013 December;28(12):2523-34.
  • Ventura Ferreira MS, Schneider RK, Wagner W, Jahnen-Dechent W, Labude N, Bovi M, Piroth DM, Knüchel R, Hieronymus T, Müller AM, Zenke M, Neuss S. 2D Polymer-based Cultures expand Cord Blood-derived Hematopoietic Stem Cells and Support Engraftment of NSG mice. Tissue Engineering Part C (Methods). 2013 Jan;19(1):25-38.
  • Koos R, Brandenburg V, Mahnken AH, Schneider RK, Dohmen G, Marx N, Kramann R. Sclerostin as potential novel biomarker for aortic valve calcification: an in vivo and ex vivo study. The Journal of Heart Valve Disease 2013, The Journal of Heart Valve Disease. 2013 May;22(3):317-25.
  • Kramann R, Brandenburg VM, Schurgers LJ, Ketteler M, Westphal S, Leisten I, Bovi M, Jahnen-Dechent W, Knüchel R, Floege J and Schneider RK. Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy. Nephrology Dialysis Transplantation. 2013 March; 28(4): 856-868.

2012

  • Mullally A, Poveromo L, Schneider RK, Al-Shahrour F, Lane SW, Ebert BL. Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F polycythemia vera. Blood. 2012 Jul 5;120(1):166-72.
  • Leisten I, Kramann R, Ventura Ferreira MS, Ziegler P, Wagner W, Neuss S, Knüchel R and Schneider RK. 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche. Biomaterials. 2012 Feb;33(6):1736-47.
  • Kramann R, Couson S, Neuss S, Floege J, Knuechel R and Schneider RK. Exposure to uremic serum disrupts the vascular niche in a three-dimensional co-culture system of human mesenchymal stem cells and human umbilical cord endothelial cells. Nephrology Dialysis Transplantation. 2012 Jul;27(7):2693-702.
  • Ventura Ferreira MS, Schneider RK, Jahnen-Dechent W, Labude N, Bovi M, Hieronymus T, Zenke M and Neuss S. Highly efficient Cord Blood-Hematopoietic Stem Cell Expansion in 3D Fibrin Scaffolds with Stromal Support. Biomaterials. 2012 Oct;33(29):6987-97.
  • Walenda G, Hemeda H, Schneider RK, Merkel R, Hoffmann B, Wagner W. Human Platelet Lysate Gel Provides a Novel 3D-Matrix for Enhanced Culture Expansion of Mesenchymal Stromal Cells. Tissue Engineering Part C Methods. 2012 Dec;18(12):924-34.
  • van de Kamp J, Kramann R, Anraths J, Schöler HR, Ko K, Knüchel R, Zenke M, Neuss S and Schneider RK. Epithelial morphogenesis of germline-derived pluripotent stem cells on organotypic skin equivalents in vitro. Differentiation. 2012 Mar; 83(3):138-47.